UGENE

UGENE 53.1

UGENE is a free open-source bioinformatics software for Windows, macOS, and Linux.

  • By Unipro
  • Open Source
  • Updated Mar 4, 2026
Download for Windows

About UGENE

UGENE is a free open-source bioinformatics software for Windows, macOS, and Linux.

What's new in 53.1

Stability fixes

Full release notes »

Technical details

PublisherUnipro
Version53.1
Release date2026-03-04
LicenseGPL-2.0
Installer typenullsoft
Architecturex64
Package IDUnipro.UGENE
Install scopeAll users

Install UGENE from the command line

Install with Windows Package Manager
winget install --id=Unipro.UGENE -e
Update to the latest version
winget upgrade --id=Unipro.UGENE -e
Uninstall
winget uninstall --id=Unipro.UGENE -e
Silent install with the offline installer
"ugene-53.1-win-x86-64.exe" /S

bioinformaticscppcross-platformdnamsangspipelineqt5sciencesequencingugeneworkflow

File types supported by UGENE

UGENE can open or be associated with 109 file types:

.ab1.ab1.gz.abi.abi.gz.abif.abif.gz.ace.ace.gz.aln.aln.gz.apr.apr.gz.bam.bed.bed.gz.diff.diff.gz.em.em.gz.emb.emb.gz.embl.embl.gz.fa.fa.gz.fas.fas.gz.fasta.fasta.gz.fastq.fastq.gz.fna.fna.gz.fpkm_tracking.fpkm_tracking.gz.fq.fq.gz.fsa.fsa.gz.gb.gb.gz.gbk.gbk.gz.gen.gen.gz.genbank.genbank.gz.gff.gff.gz.gp.gp.gz.gtf.gtf.gz.meg.meg.gz.mpfa.mpfa.gz.msf.msf.gz.newick.newick.gz.nex.nex.gz.nh.nh.gz.nhx.nhx.gz.nwk.nwk.gz.nxs.nxs.gz.pdb.pdb.gz.pdw.pdw.gz.pfm.pfm.gz.ph.ph.gz.phy.phy.gz.prt.prt.gz.sam.sam.gz.scf.scf.gz.sef.sef.gz.seq.seq.gz.seqs.seqs.gz.snp.snp.gz.sw.sw.gz.txt.txt.gz.ugenedb.uprj.uql.uql.gz.uwl.uwl.gz.uws.uws.gz.vcf.vcf.gz

UGENE version history

52.1 May 8, 2025
52.0 Jan 24, 2025

Changes
Supported file sharing directly from UGENE for files stored on workspace.ugene.net.
Added support for the Kraken tool for data analysis.
Enhanced the color scheme in the multiple alignment editor for better readability.
Fixed compatibility issues with Linux environments using pre-installed Qt.
Improved high DPI support on Linux and Windows.

51.0 Sep 22, 2024

Frequently asked questions

Is UGENE free?

Yes. UGENE is free and open-source software released under the GPL-2.0 license.

What is the latest version of UGENE?

The latest version is 53.1, released on Mar 4, 2026.

Is it safe to download UGENE?

The download button links to the official installer published on github.com, the same file Windows Package Manager installs. You can verify the downloaded file by comparing its SHA-256 checksum with 34a81d4c3c0ebdff0e1fb55af4a9891eae55a77e910ede0524e31a09b759fe09.

Which Windows versions does UGENE support?

UGENE runs on Windows and is available for 64-bit (x64) systems.

How do I install UGENE silently?

Run the offline installer with "ugene-53.1-win-x86-64.exe" /S, or install it with Windows Package Manager: winget install --id=Unipro.UGENE -e --silent.

How do I uninstall UGENE?

Open Settings › Apps › Installed apps, find UGENE and select Uninstall. From the command line, run winget uninstall --id=Unipro.UGENE -e.

What file types can UGENE open?

UGENE supports 109 file types, including .ab1, .ab1.gz, .abi, .abi.gz, .abif, .abif.gz, .ace, .ace.gz and more.

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